Since the 1980s, developing countries health and longevity has become the indicator for assessing and also, health was defined in its broad dimensions, including attention to physical, emotional, psychological, social and environmental interactions. But after decades, architects and planners have been disregarded in research, design and construction of the physical environment, and in response to the psychological needs of users. The lack of responding environment to neural needs in order to provide mental health, especially in the care, treatment and care setting has reduced the level of development of Iran with different psychological and behavioral disorders. By attention neuroscience in environmental design, it is possible to increase the environmental capability to adapt to meeting the needs of the neuropsychological of the users of the human-made environment. Improving the quality of living space and increasing the efficiency and responsiveness of the physical environment to mental needs through the consideration of the principles of neuroscience are the goals of this article. Methodology of this study was a descriptive-analytic research based on a review study and inductive qualitative content analysis was method. The findings are based on three features: architectural experience; intrinsic self-consciousness, sensory-based architecture, responses to cognitive and emotional neuropsychiatric and the architecture of all senses (multi-sensory) as a modification. Therefore, in future, the new paradigm of neuropsychological architecture will lead to changes in response to mental needs in order to develop environmental health.

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